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患者,女性,40岁。腰背痛1年,开始时为腰骶部疼痛向双臀部放射,后腰骶部痛减轻,背痛加重,并逐渐出现

驼背畸形,双髋活动部分受限,剧烈活动后气喘、呼吸困难。检查发现脊柱活动明显受限,肺活量明显减少,Thomas征阳性,血液检查RF(~),抗链球菌溶血素“0”:200U,血沉1小时54cm。初步诊断应首先考虑

A.风湿性关节炎

B.弥散性特发性骨骼骨肥厚病(DISH病)

C.强直性脊柱炎

D.脊柱结核

E.创伤性脊柱炎

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