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[多选题]

一氧化碳中毒的毒理是

A.CO与血红蛋白的亲和力比氧大

B.碳氧血红蛋白的解离度比氧合血红蛋白慢

C.CO浓度过高时可直接抑制细胞内呼吸

D.还原血红蛋白增多加重了组织缺氧

E.脑血管先扩张后痉挛而致脑水肿

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