【单选题】A 20-month-old boy is diagnosed with Hutch...
【单选题】A 20-month-old boy is diagnosed with Hutchinson-Gilford progerial syndrome (HGPS), a severe form of early-onset premature aging. Fetal and early postnatal development are normal, but there is now severe failure to thrive, some lipoatrophy, bony abnormalities, a small, beaked nose and receding mandible, hair loss, and speckled hypopigmentation with some areas of tight hard skin. His neurological and cognitive tests are normal. Genetic analysis shows a single spontaneous mutation in codon 608 of the LMNA gene, which encodes both lamin A and lamin C. Which one of the following would you most likely expect to be a direct effect in cells obtained from this patient?
A、Increased heterochromatin
B、Interference with microtubule treadmilling
C、Increased synthesis of rRNA in the nucleolus
D、Loss of ability to adhere to the basement membrane through integrins
E、Aberrations in nuclear architecture